Oncodesign Services Acquires ZoBio

We are excited to announce that ZoBio will join forces with Oncodesign Services (ODS), a leading Contract Research Organization (CRO) specializing in drug discovery and preclinical services with notable expertise in oncology and immuno-inflammation.

Compound QC at ZoBio by NMR: Structure Confirmation and Solubility Assay

Just as good quality data is essential to draw the right conclusions from experiments, so are good quality compounds. There are many ways to assess compound quality and one technique we regularly use for this purpose at ZoBio is NMR.
We start by dissolving incoming compounds in d6-DMSO to generate stock solutions for use in various assays. The advantage of using d6-DMSO is that the same stock can not only be used for biochemical and SPR assays, but also for ligand- or protein observed NMR. This way, we reduce batch to batch variance…

Small Molecule Induced Protein Complexes: Gluing the Pieces Together

We typically think of biologically relevant protein complexes forming spontaneously through surface complementarity. However, with the discovery of the mechanism of action (MoA) of Rapamycin & Cyclosporin in the early nineties, it became apparent that protein-protein interactions (PPIs) could be mediated by non-proteinaceous molecules. Furthermore, such interactions could have beneficial pharmacological effects such as the inhibition of the central regulatory kinase mTOR. Since this initial ground-breaking discovery, many other molecules…

Contributing All the Way to the Clinic

Recently the ZoBio team made an important contribution to a drug discovery project for our client Mirati Therapeutics that we are particularly proud of and has had significant impact [1]. This work describes a program to develop inhibitors of the epigenetic target PRMT5 with the potential to …