Selected Publications and Posters

TINS

Target Immobilization and NMR Screening of Fragments in Early Drug Discovery

Introduction and case studies for the technology upon which ZoBio was founded. Since then, more than 100 targets have been screened yielding thousands of hits.

SPR

Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase

KMO is an interesting target for neurological orders. Here we developed a protocol to produce biophysics grade preparations of the membrane protein. We then developed an SPR assay that was capable of reporting on both the mechanism of action and the kinetics of binding of small molecule inhibitors.

NMR

Rapid Protein−Ligand Costructures from Sparse NOE Data

X-ray crystallography is well known for providing high resolution structural information for drug discovery. When X-ray fails, solution NMR can provide an alternative route to that information. Here we developed a fast, yet robust protocol for success using NMR on proteins up to about 50 kDa.

Interesting

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