In person We are pleased to announce that Anne-Sophie Huart will be attending the upcoming Light Scattering Community Day in Amsterdam, where she will deliver a presentation entitled “SEC-MALS in Advanced Protein Analysis and Characterization“ The programme of this one day seminar will cover a broad range of topics, from the fundamentals of light scattering…
Advancing Vaccine Research for the Prevention of Urinary Tract Infections
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, with extraintestinal pathogenic Escherichia coli (ExPEC) being a major causative agent. The growing prevalence of antimicrobial resistance has increased the need for…
Lessons Learned from Molecular Glue Discovery Campaigns (Part 3)
Discovery of molecular glues is frequently perceived as serendipitous. Drawing on 12 fragment-based molecular glue screening campaigns across diverse protein pairs, we highlight here ten practical lessons that consistently influenced screening outcomes. In Part 1 and Part 2 of the series we have shown that intrinsic affinity between the protein matter and that cooperativity is key in finding moleucular glues. We have shown that molecular glues are actually way more common than expected, provided that the screening assays are well set up. In this Part…
Lessons Learned from Molecular Glue Discovery Campaigns (Part 2)
Discovery of molecular glues is frequently perceived as serendipitous. Drawing on 12 fragment-based molecular glue screening campaigns across diverse protein pairs, we highlight ten practical lessons that consistently influenced screening outcomes. In Part 1, we explored how intrinsic protein-protein affinity and thermodynamic modelling can help establish sensitive molecular glue screens. In Part 2, we turn to practical lessons from our screening campaigns, covering how to select suitable E3 ligases, identify cooperative hits, distinguish genuine glue…