Established drug targets remain attractive because they offer validated biology and a wealth of existing knowledge. Yet finding novel opportunities within well-explored target space remains a significant challenge.

In this webinar, you will learn how fragment-based drug discovery can uncover new ligandable sites and reveal unexplored opportunities on known targets. We will discuss how to assess whether fragment screening is the right strategy for your project, the importance of defining the desired mode of action early, and practical approaches for rapidly progressing promising hits.

Through case studies and real-world examples, we will demonstrate how fragment-based approaches continue to unlock new possibilities for established targets.

Many drug discovery programs struggle with challenging targets, including protein–protein interactions, shallow binding pockets, and projects that have failed to yield meaningful hits through conventional screening approaches.

Watch our webinar and find out the practical strategies for selecting the most effective discovery approach for difficult targets. Learn how fragment-based screening, covalent compounds, and DNA-encoded libraries can be combined with smart chemistry and biophysical methods to identify and rapidly advance high-quality hits.

Through selected case studies, we demonstrate how covalent compounds can modulate protein–protein interactions, including applications in molecular glue discovery. We also discuss how to distinguish genuine hits from artefacts and optimize hit quality early in the discovery process.

Learn from our experts about actionable strategies for turning difficult targets into tractable drug discovery projects!