In person
Molecular glues are rapidly emerging as a transformative modality in drug discovery, enabling novel mechanisms to modulate protein function through stabilization of protein–protein interactions. Yet discovering synthetic molecular glues de novo remains a major challenge, particularly due to the need to identify compounds that both engage a target and promote cooperative ternary complex formation.
At SLAS Europe, our colleague Pim de Vink presented a biophysics-driven framework for molecular glue discovery across challenging targets, with a particular focus on cooperativity as a guiding principle in screening and characterization strategies.
By focusing directly on ternary complex formation and cooperativity, this framework aims to lower the barrier to discovering next-generation molecular glue therapeutics.