Molecular glues are redefining how we approach drug discovery, enabling the targeting of proteins once considered “undruggable.” Unlike traditional small molecules that bind directly to a single protein, molecular glues act as mediators, stabilizing interactions between two proteins to drive a specific biological outcome. This breakthrough mechanism is particularly valuable for targeted protein degradation (TPD) and other therapeutic…

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In person Molecular glues and targeted protein degraders are revolutionizing the field of drug discovery, offering promising solutions for a range of diseases, including cancer, infectious, inflammatory, and neurodegenerative diseases. These innovative therapies are particularly beneficial for targeting previously “undruggable” pathogenic proteins. The recent emergence of the ‘molecular glue’ class of protein degraders is paving…