Upcoming events
SLAS Europe 2026
In person
ZoBio at SLAS Europe 2026!
Molecular glues are rapidly emerging as a transformative modality in drug discovery, enabling novel mechanisms to modulate protein function through stabilization of protein–protein interactions. Yet discovering synthetic molecular glues de novo remains a major challenge, particularly due to the need to identify compounds that both engage a target and promote cooperative ternary complex formation.
At SLAS Europe, our colleague Pim de Vink will present a biophysics-driven framework for molecular glue discovery across challenging targets, with a particular focus on cooperativity as a guiding principle in screening and characterization strategies.
His presentation will highlight:
- Approaches to quantitatively connect binding affinity with ternary complex stabilization
- Screening and follow-up methodologies designed to detect cooperative interactions early
- SPR-based Capture–Chase assays for mechanistic characterization of covalent molecular glues
- Strategies to identify and prioritize molecular glue candidates with greater confidence
By focusing directly on ternary complex formation and cooperativity, this framework aims to lower the barrier to discovering next-generation molecular glue therapeutics.
We look forward to connecting with colleagues and discussing how biophysics can accelerate molecular glue discovery!
Past events
3rd Biophysics for Drug Discovery Summit 2026
In person
ZoBio attended the 3rd Biophysics for Drug Discovery Summit 2026 in Boston, a unique, industry-focused forum dedicated exclusively to biophysics. Through case studies, panel discussions, and interactive exchanges, the summit highlights how emerging biophysical technologies are shaping predictive pipelines and accelerating drug discovery.
Marta Carneiro presented the poster: “Tailor-made Biophysics – A versatile toolkit for discovery and validation”, which attracted a lot of attention during the meeting.
Marta shared selected case studies demonstrating how biophysical approaches can address diverse discovery challenges – from fragment-based screening for molecular glues, to profiling covalent compounds and antibody – antigen interactions, as well as generating structural models when X-ray crystallography reaches its limits.
Curious to see how these approaches can support complex discovery programs? Download the poster to explore the case studies and insights in more detail.
Download the Poster: Tailor Made Biophysics
Therapeutic Frontiers in Medicine, Mechanisms and Modalities
In person
ZoBio was attending TFMED 2026, a four-day transdisciplinary conference dedicated to next-generation therapeutic modalities, including molecular glues, PROTACs, nucleic acid-based therapies, and cell-based approaches.
The meeting brought together researchers, clinicians, and industry experts, offering in-depth scientific sessions, direct interaction with leading specialists, and valuable opportunities for networking and collaboration, with a strong focus on early-career scientists.
Anna Belorusova presented a flash talk and poster titled: “SPR Workflows for Molecular Glue Hit Discovery.”
In her presentation, she highlighted how ZoBio supports molecular glue discovery through dedicated Surface Plasmon Resonance (SPR) workflows, complemented by a suite of orthogonal biophysical techniques. This integrated platform enables direct assessment of protein–protein interactions, supports fragment screening and validation, and provides insights into the likelihood of identifying molecular glues for specific target pairs.
By combining multiple biophysical approaches, we deliver robust characterization and mechanistic understanding of hits, helping to de-risk early-stage discovery and accelerate progress toward challenging targets