In person
ZoBio at SLAS Europe 2026!
Molecular glues are rapidly emerging as a transformative modality in drug discovery, enabling novel mechanisms to modulate protein function through stabilization of protein–protein interactions. Yet discovering synthetic molecular glues de novo remains a major challenge, particularly due to the need to identify compounds that both engage a target and promote cooperative ternary complex formation.
At SLAS Europe, our colleague Pim de Vink will present a biophysics-driven framework for molecular glue discovery across challenging targets, with a particular focus on cooperativity as a guiding principle in screening and characterization strategies.
His presentation will highlight:
- Approaches to quantitatively connect binding affinity with ternary complex stabilization
- Screening and follow-up methodologies designed to detect cooperative interactions early
- SPR-based Capture–Chase assays for mechanistic characterization of covalent molecular glues
- Strategies to identify and prioritize molecular glue candidates with greater confidence
By focusing directly on ternary complex formation and cooperativity, this framework aims to lower the barrier to discovering next-generation molecular glue therapeutics.
We look forward to connecting with colleagues and discussing how biophysics can accelerate molecular glue discovery!