Molecular glues have emerged as an exciting new class of agents in drug discovery, offering a novel mechanism to modulate protein function, both as protein degraders and for other therapeutic targets. Unlike traditional drugs that inhibit or block protein activity, molecular glues enhance or induce new protein-protein interactions (PPIs), allowing them to activate biological pathways rather than suppressing them. For instance, the natural compound Rapamycin has been used as an immunosuppressant for decades. It binds at the interface of mTOR and FKBP12 and increases the interaction between these two proteins…
Isotopic Labeling in Mammalian Expression: The Missing Link for NMR Studies of Hard-to-Express Proteins
ZoBio is excited to introduce a new exclusive capability for making complex protein samples for drug discovery: isotopic labeling during mammalian expression. This ability provides the missing link between…
Using SEC-MALS to Validate BRICHOS Oligomer Structures
The BRICHOS domain is a molecular chaperone known for its ability to prevent amyloid and amorphous protein aggregation, playing a critical role in protecting cells from protein misfolding. ZoBio has an active collaboration with the Karolinska Institutet, where we are exploring the Bri2 BRICHOS…
15th Swiss Course on Medicinal Chemistry in Leysin
In person As in previous years, ZoBio was proud to be a sponsor of the 15th Swiss Course on Medicinal Chemistry in Leysin! This five-day Medicinal Chemistry School, organized by the Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society , focuses on the most cutting-edge aspects of small molecule drug discovery, highlighting…
