Molecular glues are redefining how we approach drug discovery, enabling the targeting of proteins once considered “undruggable.” Unlike traditional small molecules that bind directly to a single protein, molecular glues act as mediators, stabilizing interactions between two proteins to drive a specific biological outcome. This breakthrough mechanism is particularly valuable for targeted protein degradation (TPD) and other therapeutic…

Molecular glues represent a groundbreaking approach in drug discovery, offering the unique ability to modulate or degrade traditionally “undruggable” targets by promoting or stabilizing protein-protein interactions. Unlike conventional small molecule inhibitors, molecular glues form ternary complexes involving two proteins and a small molecule, with their effectiveness largely driven by cooperativity—the synergistic enhancement of binding affinity through protein interaction.
Despite their therapeutic promise…