Mirati Therapeutics has selected ZoBio to provide fragment-based screening, biophysical compound characterization and structural biology for several oncology targets. In this arrangement, ZoBio screens its fragment library using both its proprietary Target Immobilized NMR Screening and SPR capabilities…
Drug Discovery Chemistry Virtual
Online Focused on discovery and optimization challenges of small molecule drug candidates, Drug Discovery Chemistry is a dynamic virtual event for medicinal and biophysical chemists working in pharma and biotech. Gregg Siegal has presented the lecture: ‘Biophysics-Based Drug Discovery for Epitranscriptomics‘ during Fragment-Based Drug Discovery session. Afterwards, together with other speakers he participated in interesting…
Axxam and ZoBio Form a Strategic Alliance Integrating their Drug Discovery Services Platforms
MILAN, IT, AND LEIDEN, NL
Axxam and ZoBio have initiated a strategic alliance to provide a combination of integrated discovery services spanning all phases from gene to fully optimized leads.
This alliance provides access to a synergistic, industry-leading…
YTHDF2 – An unprecedented epitranscriptomic reader protein
Challenge
Our client tasked us with setting up a complete “gene to lead” fragment-based drug discovery campaign.
Since the entire family is unprecedented, there were no “tool compounds” typically required to set up assays. As we progressed, further challenges presented themselves.
Achievements
By capitalizing on our unique expertise in developing customized biophysical assays, we created a biologically relevant compound screening cascade in the absence of tool compounds. The cascade delivered chemically diverse sets of validated fragments that we successfully elaborated towards lead compounds using structural information that could only be gleaned through NMR.