In person ZoBio was present in Nice at the XXVII EFMC International Symposium on Medicinal Chemistry. The 2022 program was very interesting and diverse. It covered advances in drug discovery in major therapeutic areas, including bacterial and viral infections, with a particular attention to current and emerging viral pandemics, but also neurodegenerative and cardiovascular diseases, rare diseases…
EUROMAR 2022
In person As in the previous years ZoBio attended the European Conference on Magnetic Resonance, which took place in Utrecht on the 10-14 July 2022. The organizers provided a stimulating forum to exchange on the most recent breakthroughs in magnetic resonance and to showcase the latest developments of the industrial sponsors. On Tuesday 12 July…
The Protein Society Annual Symposium
In person On July 7th Dipen Shah, our Head of Protein Sciences attended the Protein Society Annual Symposium in San Francisco, California. Dipen presented the poster: From Genes to Lead Molecules: a work-flow tuned for drugging challenging therapeutic targets using Fragment based Drug Discovery. This year symposium comprised 12 exceptional scientific sessions and nine award speakers…
Small Molecule Induced Protein Complexes: Gluing the Pieces Together
We typically think of biologically relevant protein complexes forming spontaneously through surface complementarity. However, with the discovery of the mechanism of action (MoA) of Rapamycin & Cyclosporin in the early nineties, it became apparent that protein-protein interactions (PPIs) could be mediated by non-proteinaceous molecules. Furthermore, such interactions could have beneficial pharmacological effects such as the inhibition of the central regulatory kinase mTOR. Since this initial ground-breaking discovery, many other molecules…