The Protein Society Annual Symposium

In person On July 7th Dipen Shah, our Head of Protein Sciences attended the Protein Society Annual Symposium in San Francisco, California. Dipen presented the poster: From Genes to Lead Molecules: a work-flow tuned for drugging challenging therapeutic targets using Fragment based Drug Discovery. This year symposium comprised 12 exceptional scientific sessions and nine award speakers…

Small Molecule Induced Protein Complexes: Gluing the Pieces Together

We typically think of biologically relevant protein complexes forming spontaneously through surface complementarity. However, with the discovery of the mechanism of action (MoA) of Rapamycin & Cyclosporin in the early nineties, it became apparent that protein-protein interactions (PPIs) could be mediated by non-proteinaceous molecules. Furthermore, such interactions could have beneficial pharmacological effects such as the inhibition of the central regulatory kinase mTOR. Since this initial ground-breaking discovery, many other molecules…

Contributing All the Way to the Clinic

Recently the ZoBio team made an important contribution to a drug discovery project for our client Mirati Therapeutics that we are particularly proud of and has had significant impact [1]. This work describes a program to develop inhibitors of the epigenetic target PRMT5 with the potential to …

Drug Discovery Chemistry

Hybrid Drug Discovery Chemistry is a dynamic conference for medicinal chemists working in pharma and biotech. Focused on discovery and optimization challenges of small molecule drug candidates, this event provides many exciting opportunities for scientists. Our CEO Gregg Siegal attended the event and participated in many interesting and educational discussions. Conference website