Imagine you’ve just titrated 50 compounds using any modern assay and instrumentation. The software is certainly capable of automatically extracting the response for each concentration and fitting it to extract the affinity/potency. You might then see the curve above (Figure 1) and the fit values in a table. If the affinity or potency is in the range you expect, with a quick look, the binding curve might pass muster with a possible note that the compound has some solubility issues at the highest concentration used. You might then pass on the data to the medicinal chemist, unfortunately that would be a mistake…
The Craft of NMR Spectroscopy for Designing Novel Molecules
Performing impactful research requires craftsmanship on the part of the experimenter. Since ZoBio believes that the combination of craftsmanship and leading edge technology will yield impactful insights, we take our responsibility to educate the next generation of scientists seriously. Therefore, ZoBio has participated in the…
The ZoBio Fragment Library: Chemically Diverse Starting Points for Drug Discovery
ZoBio strives to provide attractive, validated chemical starting points for your drug discovery projects. To achieve this goal, we have been building and maintaining the ZoBio fragment library since 2003. Our fragment library has been screened against more than 100 targets…
Mirati and ZoBio Collaborate to Advance Targeted Oncology Programs
Mirati Therapeutics has selected ZoBio to provide fragment-based screening, biophysical compound characterization and structural biology for several oncology targets. In this arrangement, ZoBio screens…