![](/online/wp-content/uploads/2022/07/blog.jpg")
Molecular glues are redefining how we approach drug discovery, enabling the targeting of proteins once considered “undruggable.” Unlike traditional small molecules that bind directly to a single protein, molecular glues act as mediators, stabilizing interactions between two proteins to drive a specific biological outcome. This breakthrough mechanism is particularly valuable for targeted protein degradation (TPD) and other therapeutic…
Precision Discovery and Structure-Guided Development of Molecular Glues
Molecular glues represent a groundbreaking approach in drug discovery, offering the unique ability to modulate or degrade traditionally “undruggable” targets by promoting or stabilizing protein-protein interactions. Unlike conventional small molecule inhibitors, molecular glues form ternary complexes involving two proteins and a small molecule, with their effectiveness largely driven by cooperativity—the synergistic enhancement of binding affinity through protein interaction.
Despite their therapeutic promise…
Meet the ZoBio SPR Team: Advancing Drug Discovery Around the Clock
Drug discovery doesn’t sleep, and neither does our SPR (Surface Plasmon Resonance) team. While the Assay Group takes a well-deserved weekend break and goes for dinner tonight, our relentless SPR team is tirelessly screening compounds, revealing critical insights that help drive discovery forward.
Meet the Team:
Each of our SPR machines brings unique strengths to the lab, earning their names and personalities for how they support our research. These workhorses are the true heroes of our lab, capturing precise data…
Molecular Glues Discovery
Molecular glues have emerged as an exciting new class of agents in drug discovery, offering a novel mechanism to modulate protein function, both as protein degraders and for other therapeutic targets. Unlike traditional drugs that inhibit or block protein activity, molecular glues enhance or induce new protein-protein interactions (PPIs), allowing them to activate biological pathways rather than suppressing them. For instance, the natural compound Rapamycin has been used as an immunosuppressant for decades. It binds at the interface of mTOR and FKBP12 and increases the interaction between these two proteins…