{"id":4218,"date":"2024-01-11T14:34:16","date_gmt":"2024-01-11T14:34:16","guid":{"rendered":"https:\/\/zobio.com\/?p=4218"},"modified":"2024-01-11T14:36:42","modified_gmt":"2024-01-11T14:36:42","slug":"zobio-is-a-crystallography-company-too","status":"publish","type":"post","link":"https:\/\/zobio.com\/online\/news\/zobio-is-a-crystallography-company-too\/","title":{"rendered":"ZoBio is a Crystallography Company (Too)"},"content":{"rendered":"<div id=\"pl-4218\"  class=\"panel-layout\" ><div id=\"pg-4218-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-4218-0\" ><div id=\"pgc-4218-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-4218-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"with-icon panel-widget-style panel-widget-style-for-4218-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h2 class=\"widget-title\">ZoBio is a Crystallography Company (Too)<\/h2>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Many still think of ZoBio as an NMR company. And while NMR will always have a special place in our hearts, we also have a thriving crystallography team!<\/p>\n<p>Detailed and timely structural information is a cornerstone of rational drug design and X-ray crystallography plays a key role in most structure-based approaches. \u00a0A year ago, we completed a strategic investment in building a robust <a href=\"https:\/\/zobio.com\/online\/news\/the-upgrade-of-our-x-ray-crystallography-infrastructure-completed\/\">X-ray crystallography workflow<\/a> and our protein crystallography capabilities have now matured into a fully integrated, <strong>H<\/strong>igh-<strong>T<\/strong>hroughput (HT) platform, thanks to in-house developments and customizations that augment our industry standard instrumentation.<\/p>\n<p>Our infrastructure supports HT ligand soaking and co-crystallization protocols and both have been used with great success. A custom-made climate chamber with both temperature and humidity control ensures maximum reproducibility of crystallization and allows us to reliably harvest even very small or thin crystals without degradation or dehydration. This instrumentation ensures precise and highly reproducible experiments for the most sensitive proteins and crystals.<\/p>\n<p>Once a robust crystallization system is established, our proprietary in-house algorithms allow us to soak 96-samples in a matter of minutes enabling screening of very large numbers of compounds. This compound screening capacity is complemented by frequent scheduled visits to synchrotrons and our automated data processing pipeline based around the <strong>PanDDA<\/strong> multi-dataset analysis package which further enables timely structural information with great sensitivity.<\/p>\n<p>Striking a balance between automation and customization, our crystallography platform has supported over 15 integrated drug discovery projects in the last year, both on unprecedented and on previously described targets, using soaking and co-crystallization approaches, enabling SBDD for reversible and covalent small molecules alike. Finally, the tight integration of our structural biologists with our protein production group has allowed us to engineer proteins that yield crystals of highly validated targets that have previously been refractory to <strong>3D<\/strong> structure elucidation.<\/p>\n<p>Our entire pipeline is highly customizable allowing us to easily meet our client\u2019s needs and target\u2019s demands \u2013 with the usual creativity we are known for.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Many still think of ZoBio as an NMR company. And while NMR will always have a special place in our hearts, we also have a thriving crystallography team!<br \/>\nDetailed and timely structural information is a cornerstone of rational drug design and X-ray crystallography plays a key role in most&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"gpsa_enabled":false,"gpsa_required_form_ids":[],"gpsa_require_unique_form_submission":false,"gpsa_access_behavior":"show_message","gpsa_form_redirect_path":"","gpsa_requires_access_message":"","gpsa_access":[],"gpsa_content_loading_message":"","footnotes":""},"categories":[3],"tags":[],"class_list":["post-4218","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ZoBio is a Crystallography Company (Too) - ZoBio - Drug Discovery Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zobio.com\/online\/news\/zobio-is-a-crystallography-company-too\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ZoBio is a Crystallography Company (Too) - ZoBio - Drug Discovery Technology\" \/>\n<meta property=\"og:description\" content=\"Many still think of ZoBio as an NMR company. 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