{"id":3243,"date":"2021-10-22T09:09:14","date_gmt":"2021-10-22T09:09:14","guid":{"rendered":"https:\/\/zobio.com\/?p=3243"},"modified":"2022-05-24T10:55:56","modified_gmt":"2022-05-24T10:55:56","slug":"scientist-in-nmr-based-rna-drug-discovery-phd","status":"publish","type":"post","link":"https:\/\/zobio.com\/online\/geen-categorie\/scientist-in-nmr-based-rna-drug-discovery-phd\/","title":{"rendered":"Scientist in NMR-based RNA Drug Discovery (PhD)"},"content":{"rendered":"<div id=\"pl-3243\"  class=\"panel-layout\" ><div id=\"pg-3243-0\"  class=\"panel-grid panel-has-style\" ><div class=\"main-image-career siteorigin-panels-stretch panel-row-style panel-row-style-for-3243-0\" data-stretch-type=\"full-stretched\" ><div id=\"pgc-3243-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3243-0-0-0\" class=\"so-panel widget widget_sow-image panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-image so-widget-sow-image-default-c67d20f9f743-3243\"\n\t\t\t\n\t\t>\n<div class=\"sow-image-container\">\n\t\t<img \n\tsrc=\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2.jpg\" width=\"2560\" height=\"706\" srcset=\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2.jpg 2560w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2-300x83.jpg 300w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2-1024x282.jpg 1024w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2-768x212.jpg 768w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2-1536x424.jpg 1536w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2021\/03\/pipetten2-2048x565.jpg 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" alt=\"\" \t\tclass=\"so-widget-image\"\/>\n\t<\/div>\n\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-3243-1\"  class=\"panel-grid panel-has-style\" ><div class=\"print-this panel-row-style panel-row-style-for-3243-1\" ><div id=\"pgc-3243-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3243-1-0-0\" class=\"so-panel widget widget_siteorigin-panels-post-content panel-first-child\" data-index=\"1\" ><div class=\"career-title panel-widget-style panel-widget-style-for-3243-1-0-0\" ><h1 class=\"entry-title\">Scientist in NMR-based RNA Drug Discovery (PhD)<\/h1><\/div><\/div><div id=\"panel-3243-1-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"2\" ><div class=\"career-date panel-widget-style panel-widget-style-for-3243-1-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>22 OCTOBER 2021<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-1-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"3\" ><div class=\"panel-widget-style panel-widget-style-for-3243-1-0-2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>ZoBio (<a href=\"http:\/\/www.zobio.com\/\">www.zobio.com<\/a>) was founded in 2004 and is located in Leiden, Netherlands. We offer innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of over 35 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology and Medicinal Chemistry.<\/p>\n<p>We are looking for a highly motivated <strong>scientist<\/strong> to drive a collaborative project involving ZoBio and Peter G\u00fcntert\u2019s and Roland Riek\u2019s groups at the ETH Z\u00fcrich. The goal of the project is to establish an automated pipeline enabling structure-based drug discovery (SBDD) using NMR for RNA targets, using machine learning to automate the (re-) assignment of RNA resonances and elucidate the structure of RNA-ligand complexes. The project will run for 3 years.<\/p>\n<p>In this position you will be able to work independently\u00a0in a highly collaborative environment within the Structural Biology group and will effectively cooperate with other research groups at ZoBio.\u00a0You will be an employee of ZoBio and it is expected that you will participate significantly in other (commercial) projects within ZoBio as well.<\/p>\n<p><em><strong>RESPONSIBILITIES<\/strong><\/em><\/p>\n<ul>\n<li>Development of workflows for RNA sample preparation at ZoBio<\/li>\n<li>Implementation and optimization of pulse sequences for RNA assignment and structure determination by solution NMR<\/li>\n<li>Implementation and testing the performance of algorithms developed by the partners at ETH Z\u00fcrich<\/li>\n<li>Planning and execution of all the experimental work with periodic reporting to the ZoBio management, funding agency, and collaborative partners<\/li>\n<\/ul>\n<p><em><strong>REQUIREMENTS<\/strong><\/em><\/p>\n<ul>\n<li>PhD in relevant field with experience in an industrial or collaborative setting and a strong background in NMR spectroscopy<\/li>\n<li>Experience with data acquisition and analysis for resonance assignment and structure determination of macromolecules by solution NMR<\/li>\n<li>Experience with RNA sample preparation for solution NMR studies and with RNA isotope labelling is a plus<\/li>\n<li>Ability to work in a team in a result-driven, goal-oriented environment<\/li>\n<li>Strong analytical and problem-solving skills<\/li>\n<li>Excellent written and verbal communication skills (English)<\/li>\n<\/ul>\n<p>A tailored remuneration package will be proposed in line with individual qualifications and experience. Please send your CV, motivation letter and names of potential referees at &lt;<a href=\"mailto:hrm@zobio.com\">hrm@zobio.com<\/a><u>&gt;<\/u> with the subject: \u201cScientist in NMR-based RNA drug discovery\u201d.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-1-0-3\" class=\"so-panel widget widget_sow-editor\" data-index=\"4\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-3243-1-0-3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/zobio.com\/online\/online\/wp-content\/uploads\/2021\/10\/20220311_DiscoveRNA_postdoc_ZoBio.pdf\">Download position (PDF)<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-1-0-4\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"5\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-3243-1-0-4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a id=\"flip-1\" href=\"#applyjob\" title=\"dynamic title?\">Apply for this Job<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-3243-1-1\"  class=\"panel-grid-cell\" ><div id=\"panel-3243-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"6\" ><div class=\"quote panel-widget-style panel-widget-style-for-3243-1-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>What is <br \/>your next <br \/>discovery?<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-1-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"7\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-3243-1-1-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/zobio.com\/online\/careers\/\" title=\"More careers at ZoBio\">More careers<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-3243-2\"  class=\"panel-grid panel-has-style\" ><div class=\"hide-print panel-row-style panel-row-style-for-3243-2\" ><div id=\"pgc-3243-2-0\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><div id=\"pgc-3243-2-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-3243-2-1\" ><div id=\"panel-3243-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"8\" ><div class=\"career-blue-block-heading panel-widget-style panel-widget-style-for-3243-2-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Have any questions? Contact us for more information on career opportunities at ZoBio<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-2-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"9\" ><div class=\"zobio-links career-blue-block-link panel-widget-style panel-widget-style-for-3243-2-1-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/zobio.com\/online\/contact\/\" title=\"Get in contact with ZoBio\" style=\"color:#FFF;\">Contact us<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-3243-3\"  class=\"panel-grid panel-has-style\" ><div class=\"hide-print panel-row-style panel-row-style-for-3243-3\" id=\"panel-1\" ><div id=\"pgc-3243-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3243-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"10\" ><div id=\"applyjob\" class=\"panel-widget-style panel-widget-style-for-3243-3-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-3-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"11\" ><div class=\"xzobio-links panel-widget-style panel-widget-style-for-3243-3-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Start your Discovery now, apply for this job at ZoBio<\/h2>\n<h3>Personal information<\/h3>\n<p>[contact-form-7 id=\"2263\" title=\"Job application\"]<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-3243-4\"  class=\"panel-grid panel-has-style\" ><div class=\"hide-print panel-row-style panel-row-style-for-3243-4\" id=\"panel-2\" ><div id=\"pgc-3243-4-0\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><div id=\"pgc-3243-4-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-3243-4-1\" ><div id=\"panel-3243-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"12\" ><div class=\"career-blue-block-heading panel-widget-style panel-widget-style-for-3243-4-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Meet the team! Meet your future colleagues working at ZoBio<\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3243-4-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"13\" ><div class=\"zobio-links career-blue-block-link panel-widget-style panel-widget-style-for-3243-4-1-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"\/about-zobio\/\" title=\"About ZoBio\" style=\"color:#FFF;\">About ZoBio<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Fulltime<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"gpsa_enabled":false,"gpsa_required_form_ids":[],"gpsa_require_unique_form_submission":false,"gpsa_access_behavior":"show_message","gpsa_form_redirect_path":"","gpsa_requires_access_message":"","gpsa_access":[],"gpsa_content_loading_message":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-3243","post","type-post","status-publish","format-standard","hentry","category-geen-categorie"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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