{"id":2803,"date":"2021-06-09T08:01:56","date_gmt":"2021-06-09T08:01:56","guid":{"rendered":"https:\/\/zobio.com\/?page_id=2803"},"modified":"2022-07-13T07:18:43","modified_gmt":"2022-07-13T07:18:43","slug":"publications-and-posters","status":"publish","type":"page","link":"https:\/\/zobio.com\/online\/publications-and-posters\/","title":{"rendered":"Publications and Posters"},"content":{"rendered":"<div id=\"pl-2803\"  class=\"panel-layout\" ><div id=\"pg-2803-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-2803-0\" data-stretch-type=\"full-stretched\" ><div id=\"pgc-2803-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-2803-0-0-0\" class=\"so-panel widget widget_sow-image panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-image so-widget-sow-image-default-c67d20f9f743-2803\"\n\t\t\t\n\t\t>\n<div class=\"sow-image-container\">\n\t\t<img \n\tsrc=\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications.jpg\" width=\"2560\" height=\"705\" srcset=\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications.jpg 2560w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications-300x83.jpg 300w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications-1024x282.jpg 1024w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications-768x212.jpg 768w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications-1536x423.jpg 1536w, https:\/\/zobio.com\/online\/wp-content\/uploads\/2022\/07\/publications-2048x564.jpg 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" alt=\"\" \t\tclass=\"so-widget-image\"\/>\n\t<\/div>\n\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-2803-1\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-2803-1\" ><div id=\"pgc-2803-1-0\"  class=\"panel-grid-cell panel-grid-cell-mobile-last\" ><div id=\"panel-2803-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div class=\"with-icon panel-widget-style panel-widget-style-for-2803-1-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h2 class=\"widget-title\">Selected Publications and Posters<\/h2>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-2803-1-1\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><\/div><\/div><div id=\"pg-2803-2\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-2803-2\" ><div id=\"pgc-2803-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-2803-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-2803-2-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h2 class=\"widget-title\">TINS<\/h2>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div><span lang=\"EN-US\"><strong>Target Immobilization and NMR Screening of Fragments in Early Drug Discovery<\/strong><\/span><\/div>\n<div>\n<p>Introduction and case studies for the technology upon which ZoBio was founded. Since then, more than 100 targets have been screened yielding thousands of hits.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-2803-2-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"3\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-2803-2-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/www.eurekaselect.com\/85441\/article\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-2803-2-1\"  class=\"panel-grid-cell\" ><div id=\"panel-2803-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\" ><div class=\"panel-widget-style panel-widget-style-for-2803-2-1-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h2 class=\"widget-title\">SPR<\/h2>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div><strong>Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase<\/strong><\/div>\n<div>\n<p>KMO is an interesting target for neurological orders. Here we developed a protocol to produce biophysics grade preparations of the membrane protein. We then developed an SPR assay that was capable of reporting on both the mechanism of action and the kinetics of binding of small molecule inhibitors.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-2803-2-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"5\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-2803-2-1-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/adt.2015.649\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-2803-2-2\"  class=\"panel-grid-cell\" ><div id=\"panel-2803-2-2-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"6\" ><div class=\"panel-widget-style panel-widget-style-for-2803-2-2-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h2 class=\"widget-title\">NMR<\/h2>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<div><strong>Rapid Protein\u2212Ligand Costructures from Sparse NOE Data<\/strong><\/div>\n<div>\n<p>X-ray crystallography is well known for providing high resolution structural information for drug discovery. When X-ray fails, solution NMR can provide an alternative route to that information. Here we developed a fast, yet robust protocol for success using NMR on proteins up to about 50 kDa.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-2803-2-2-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"7\" ><div class=\"zobio-links panel-widget-style panel-widget-style-for-2803-2-2-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jm301396d\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-2803-5\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-2803-5\" data-stretch-type=\"full-stretched\" ><div id=\"pgc-2803-5-0\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-2803-5-0\" ><div id=\"panel-2803-5-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"10\" ><div class=\"quote animate-69dfdaeba635f201415777 panels-animation-hide panel-widget-style panel-widget-style-for-2803-5-0-0\" data-so-animation=\"{&quot;selector&quot;:&quot;.animate-69dfdaeba635f201415777&quot;,&quot;animation&quot;:&quot;slideInLeft&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;duration&quot;:0.5,&quot;repeat&quot;:0,&quot;hide&quot;:1,&quot;disableAnimationMobile&quot;:0,&quot;finalState&quot;:&quot;visible&quot;,&quot;delay&quot;:0,&quot;debounce&quot;:0.1,&quot;event&quot;:&quot;enter&quot;,&quot;offset&quot;:0}\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Tailoring research to your specific needs.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-2803-5-1\"  class=\"panel-grid-cell\" ><div id=\"panel-2803-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"11\" ><div class=\"cta-home zobio-links animate-69dfdaeba6407083577818 panels-animation-hide panel-widget-style panel-widget-style-for-2803-5-1-0\" data-so-animation=\"{&quot;selector&quot;:&quot;.animate-69dfdaeba6407083577818&quot;,&quot;animation&quot;:&quot;slideInRight&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;duration&quot;:0.5,&quot;repeat&quot;:0,&quot;hide&quot;:1,&quot;disableAnimationMobile&quot;:0,&quot;finalState&quot;:&quot;visible&quot;,&quot;delay&quot;:0,&quot;debounce&quot;:0.1,&quot;event&quot;:&quot;enter&quot;,&quot;offset&quot;:0}\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact us for more information on how we can help your projects succeed!<\/p>\n<p><a href=\"\/contact\">Contact us<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Selected Publications and Posters TINS Target Immobilization and NMR Screening of Fragments in Early Drug Discovery Introduction and case studies for the technology upon which ZoBio was founded. Since then, more than 100 targets have been screened yielding thousands of hits. Read more SPR Development of a Surface Plasmon Resonance Assay for the Characterization of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"gpsa_enabled":false,"gpsa_required_form_ids":[],"gpsa_require_unique_form_submission":false,"gpsa_access_behavior":"show_message","gpsa_form_redirect_path":"","gpsa_requires_access_message":"","gpsa_access":[],"gpsa_content_loading_message":"","footnotes":""},"class_list":["post-2803","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publications and Posters - ZoBio - Drug Discovery Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zobio.com\/online\/publications-and-posters\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications and Posters - ZoBio - Drug Discovery Technology\" \/>\n<meta property=\"og:description\" content=\"Selected Publications and Posters TINS Target Immobilization and NMR Screening of Fragments in Early Drug Discovery Introduction and case studies for the technology upon which ZoBio was founded. Since then, more than 100 targets have been screened yielding thousands of hits. Read more SPR Development of a Surface Plasmon Resonance Assay for the Characterization of...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zobio.com\/online\/publications-and-posters\/\" \/>\n<meta property=\"og:site_name\" content=\"ZoBio - Drug Discovery Technology\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-13T07:18:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/zobio.com\/online\/publications-and-posters\/\",\"url\":\"https:\/\/zobio.com\/online\/publications-and-posters\/\",\"name\":\"Publications and Posters - ZoBio - Drug Discovery Technology\",\"isPartOf\":{\"@id\":\"https:\/\/zobio.com\/online\/#website\"},\"datePublished\":\"2021-06-09T08:01:56+00:00\",\"dateModified\":\"2022-07-13T07:18:43+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/zobio.com\/online\/publications-and-posters\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/zobio.com\/online\/publications-and-posters\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/zobio.com\/online\/publications-and-posters\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/zobio.com\/online\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications and Posters\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/zobio.com\/online\/#website\",\"url\":\"https:\/\/zobio.com\/online\/\",\"name\":\"ZoBio - Drug Discovery Technology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/zobio.com\/online\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/zobio.com\/online\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/zobio.com\/online\/#organization\",\"name\":\"ZoBio - Drug Discovery Technology\",\"url\":\"https:\/\/zobio.com\/online\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/zobio.com\/online\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2020\/01\/primary_logo_diap-ZoBio-RGBS.png\",\"contentUrl\":\"https:\/\/zobio.com\/online\/wp-content\/uploads\/2020\/01\/primary_logo_diap-ZoBio-RGBS.png\",\"width\":300,\"height\":371,\"caption\":\"ZoBio - Drug Discovery Technology\"},\"image\":{\"@id\":\"https:\/\/zobio.com\/online\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications and Posters - ZoBio - Drug Discovery Technology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zobio.com\/online\/publications-and-posters\/","og_locale":"en_GB","og_type":"article","og_title":"Publications and Posters - ZoBio - Drug Discovery Technology","og_description":"Selected Publications and Posters TINS Target Immobilization and NMR Screening of Fragments in Early Drug Discovery Introduction and case studies for the technology upon which ZoBio was founded. Since then, more than 100 targets have been screened yielding thousands of hits. Read more SPR Development of a Surface Plasmon Resonance Assay for the Characterization of...","og_url":"https:\/\/zobio.com\/online\/publications-and-posters\/","og_site_name":"ZoBio - Drug Discovery Technology","article_modified_time":"2022-07-13T07:18:43+00:00","twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/zobio.com\/online\/publications-and-posters\/","url":"https:\/\/zobio.com\/online\/publications-and-posters\/","name":"Publications and Posters - ZoBio - Drug Discovery Technology","isPartOf":{"@id":"https:\/\/zobio.com\/online\/#website"},"datePublished":"2021-06-09T08:01:56+00:00","dateModified":"2022-07-13T07:18:43+00:00","breadcrumb":{"@id":"https:\/\/zobio.com\/online\/publications-and-posters\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zobio.com\/online\/publications-and-posters\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/zobio.com\/online\/publications-and-posters\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/zobio.com\/online\/"},{"@type":"ListItem","position":2,"name":"Publications and Posters"}]},{"@type":"WebSite","@id":"https:\/\/zobio.com\/online\/#website","url":"https:\/\/zobio.com\/online\/","name":"ZoBio - Drug Discovery Technology","description":"","publisher":{"@id":"https:\/\/zobio.com\/online\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zobio.com\/online\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/zobio.com\/online\/#organization","name":"ZoBio - Drug Discovery Technology","url":"https:\/\/zobio.com\/online\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/zobio.com\/online\/#\/schema\/logo\/image\/","url":"https:\/\/zobio.com\/online\/wp-content\/uploads\/2020\/01\/primary_logo_diap-ZoBio-RGBS.png","contentUrl":"https:\/\/zobio.com\/online\/wp-content\/uploads\/2020\/01\/primary_logo_diap-ZoBio-RGBS.png","width":300,"height":371,"caption":"ZoBio - Drug Discovery Technology"},"image":{"@id":"https:\/\/zobio.com\/online\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/pages\/2803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/comments?post=2803"}],"version-history":[{"count":59,"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/pages\/2803\/revisions"}],"predecessor-version":[{"id":3688,"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/pages\/2803\/revisions\/3688"}],"wp:attachment":[{"href":"https:\/\/zobio.com\/online\/wp-json\/wp\/v2\/media?parent=2803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}